Overclocking with the A7M266 generally proves to be a positive experience. Drawing upon the successful A7V approach, Asus has provided functions to overclocking through both BIOS and PCB-level jumpers. Front-side bus speeds are selectable from 100 to 180 MHz in 1 MHz increments. Voltage manipulation is also allowed, with settings for the processor core ranging from 1.1v to 1.85v in 0.05v steps. Also, as with the earlier A7V, the board's I/O voltage can be altered, except the A7M supports split voltages for the separate clock generator and chipset/memory buses. These amounts can be increased by up to .26v and .2v respectably for maximum overclocking stability.

Processor multiplier manipulation is still potentially a "grey" area. Earlier revision 1.01 boards featured dipswitch support for multiplier settings ranging from 5.0 to 12.5x. In contrast, the newer revision 1.03 boards lack this valuable option. A similar scenario happened with the A7V, as some board revisions lacked multiplier support. The unusual aspect is that the later revision A7M266s still feature the etched PCB labeling for the proper dipswitch settings. Since the multiplier adjustment capability is an integral part of the overclocking experience, be sure to verify with the vendor about this issue before purchasing the A7M266.